Dr. Ajay Kumar Dang

Address :

Dairy Cattle Physiology Division, ICAR-NDRI, Karnal

Google Scholar Link: ORCID 0000-0002-7306-5302
https://scholar.google.com/citations?user=XYNwpKoAAAAJ&hl=hi

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We are working on immune cells particularly phagocytes, their role in tissue remodelling, wound healing, maintaining homeostasis during parturition, expulsion of placenta, metritis and mastitis. We discovered that neutrophils are capable of detecting the presence of an implanting embryo in the female reproductive tract. We are studying the role played by colostrum cells in host defense system of neonate calves. Studies are ongoing under field conditions for evaluating milk somatic cells to improve milk quality and mammary health. Our findings have tremendous potential in developing novel therapeutic approaches for immunocompromised animals. Have organized National Workshop on Immunophysiology and supervised 12 Masters and 6 Doctorate student projects (including 2 International students).

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Teaching as Course Incharge:

Sr. No.	Course No.	Theory /Practical
1	AP-611 (Hematology, Cardiovascular and Respiratory Physiology)	Theory and Practical
2	AP-622 (Physiology of Lactation)	Theory and Practical
3	AP-714 (Advances In Biosynthesis and Secretion of Milk)	Theory
4	AP-724 (Advances in Immunophysiology)	Theory

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Training undergone:

Sr. No.	Name of course	Organization	Duration	Nature of course
1	Refresher course in recent advances in Agricultural research project management	NAARM, Hyderabad	(21 days) 18th Sept, 2002 to 08 Oct., 2002	Research project management cycle, Monitoring and Evaluations of research projects, Impact assessment of agricultural research
2	Recent Advances in Expression Genomic Techniques.	NDRI, Karna	(21 days) Feb. 20th to March 12th 2007.	Extraction of RNA and gene expression studies
3	Advance training under DST-DAAD project	Technical University Munich, Germany	(30 days) 14th Oct. 2009 – 12th Nov. 2009	Mechanisms of cholesterol transfer into milk-a comparative gene expression and metabolism study in buffaloes and cattle.
4	Advance training under DST-DAAD project	Technical University Munich, Germany	(30 days) 5th Oct. 2010 – 3rd Nov. 2010	Isolation and culture of mammary epithelial cells

Sr. No.	Name of Award	Year	Awarding Body
1	Young Scientist Award (Ph.D. student)	2021	SAPICON 2021 (25-26 February, 2021) Bihar Veterinary College, Patna
2	2nd Best Oral Paper Presentation Award	2020	National Conference held at Post Graduate Institute of Veterinary Education and Research, Jaipur during February 4-6, 2020.
3	Dr. (Mrs.) Mridula Kamboj Young Scientist Best Doctoral Thesis Award to Ph.D. Student	2019	9th Annual Meeting of the ISSRF held at Jawaharlal Nehru University, New Mehrauli Road, New Delhi-110067
4	J.N.Pandey Memorial Best poster award	2018	Society of Animal Physiologists of India (SAPI) Conference, 2018
5	Best research paper award	2018	SAPI Conference, 2018
6	SC Sood Memorial Best Doctoral Thesis Award to Ph.D. Student	2018	SAPI Conference, 2018
7	Second prize for best paper and Rs. 3000/-	2017	45th Dairy Industry Conference held at Mumbai by Indian Dairy Association (IDA)
8	J.N.Pandey Memorial Best poster award for best Poster SAPI- (Mhow)	2016	SAPI Conference, 2016
9	Best Master’s thesis award in the Production group to Master’s student	2015	ICAR-NDRI, Karnal
10	Best Research Paper Award	2014	2nd Annual Meeting of Society of Veterinary Science and Biotechnology
11	Best Poster Paper Award	2014	9th National Convention of Indian Dairy Engineers Association (IDEA)
12	Kamala Madan Young Scientist Best Doctoral Thesis Award to Ph.D. Student	2014	SAPI Conference, 2014
13	Best Poster Paper Award	2013	2nd National IAVNAW Conference, Jammu
14	Best poster paper	2007	International Conference on Dairy Foods, NDRI, Karnal
15	First prize for Technical Bulletin in Hindi	2005	ICAR-NDRI, Karnal
16	Second Prize for Best Paper	2005	Indian Dairy Assoc.,New Delhi
17	Dr. D.N. Mullick Memorial Award	2002	Alumni Association, NDRI, Karnal
18	Dr. P.K. Dwarkanath Young Scientists Memorial Award	2002	Alumni Association, NDRI, Karnal
19	Dr. D. Sunderasen Memorial Award	2002	Alumni Association, NDRI, Karnal

Consultancy provided:

Estimation of Total immunoglobulins, IgG, IgA and IgM in dry milk colostrums powders to Supreme Dairy Farm, Mumbai and Merck, Ltd., Worli, Mumbai. Training on estimation of milk SCC provided to Gopal Jee Dairy Foods, VRS Foods Limited, PARAS Dairies.

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Research Projects

Externally funded projects:

Sr. No.	Title of Project	Funding Agency	Role
1	Modulating the immune-cellular components and their signalling molecules in bovine colostrum and milk after micro-nutrient interventions and their functional validation under ex-vivo, in vivo animal models	DBT	P.I.
2	Neutrophils as potential biomarkers/ predictors of early pregnancy in cows	DBT	P.I.
3	Assessment of early pregnancy by analysis of neutrophil dynamics and gene expression in dairy cattle	DBT	P.I.
4	Molecular basis for modulation of immunocompetence of neutrophilic function in vivo and in vitro of high producing cows and buffaloes peripartum	DBT	P.I.
5	Whole genome based SNP mining and development of breed signatures for dairy and dual-purpose indigenous cattle	DBT	CCPI
6	Development of Phytopharmaceutical product for Bovine Mastitis	CSIR-DBT	CCPI
7	Applications of probiotics in alleviating allergic responses and immunosenescence	DBT	Co-PI
8	Cloning, expression and functional characterization of a mammary gland protein MGP-40 expressed during involution and exploring its potential as a prognostic mammary biomarker in farm animals	DBT	Co-PI
9	Analysis of mammary gland transcriptome and proteome during lactation and involution in indigenous cattle and buffalo for identification of probable mammary biomarkers	NAIP	Co-PI
10	Mechanisms of cholesterol transfer into milk-a comparative gene expression and metabolism study in buffalo and cattle	DST-DAAD	Co-PI
11	Role of probiotic lactobacilli in modulation of intestinal epithelium mediated barrier functions and immune signals	DBT	Co-PI
12	Confirmation of lactation performance and safety of dairy animals of Bos species treated with recombinant bovine somatotropin (rBST)	Consultancy (ELANCO)	Co-PI
13	Testing Jeevan Pashudhan (Penergetic T), Jeevan Pashudhan Ultra (Penergetic M) for improved immunity, prevention of mastitis in dairy animals	Consultancy (PANERGETIC)	Co-PI

Research papers published (Ten best publications of last 5 years):

Sr. No.	Details
1	Alhussien, M.N., Tiwari, S., Panda, B.K., Pandey, Y., Lathwal, S.S. and Dang, A.K. (2021) Supplementation of antioxidant micronutrients reduces stress and improves immune function/response in periparturient dairy cows and their calves.Journal of Trace Elements in Medicine and Biology, p.126718. (NAAS rating 2021: 9.25)
2	Alhussien, M.N. and Dang, A.K. (2020)Sensitive and rapid lateral-flow assay for early detection of subclinical mammary infection in dairy cows. Scientific Reports,10(1), p.11161. (NAAS rating 2021: 10.00)
3	Panda, B.S., Mohapatra, S.K., Chaudhary, D., Alhussien, M.N., Kapila, R. and Dang, A.K. (2020) Proteomics and transcriptomics study reveals the utility of ISGs as novel molecules for early pregnancy diagnosis in dairy cows. Journal of Reproductive Immunology, 140, p.103148. (NAAS rating 2021: 10.02)
4	Mohapatra, S.K., Panda, B.S., Verma, A.K., Kapila, R. and Dang, A.K. (2020) Implantation associated changes in expression profile of indoleamine-2, 3-dioxygenase 1, Th1-Th2 cytokines and interferon-stimulated genes on neutrophils and peripheral blood mononuclear cells of crossbred cows. Journal of Reproductive Immunology, 142, p.103188. (NAAS rating 2021: 10.02)
5	Panda, B.S., Mohapatra, S.K., Verma, A.K., Kamboj, A., Alhussien, M.N. and Dang, A.K. (2020). A comparative study on various immunological parameters influencing embryo survivability in crossbred dairy cows. Theriogenology, 157, pp.140-148. (NAAS rating 2021: 8.09)
6	Manjari, P., Hyder, I., Kapoor, S., Senthilnathan, M. and Dang, A.K. (2018) Exploring the concentration‐dependent actions of interferon‐τ on bovine neutrophils to understand the process of implantation. Journal of Cellular Biochemistry, 119(12), pp.10087-10094 (NAAS rating 2021: 10.24)
7	Alhussien, M.N. and Dang, A.K. (2018) Impact of different seasons on the milk somatic and differential cell counts, milk cortisol and neutrophils functionality of three Indian native breeds of cattle. Journal of Thermal Biology, 78. 10.1016/j.jtherbio.2018.08.020.(NAAS rating 2021: 8.36)
8	Alhussien, M.N. and Dang, A.K. (2018) Pathogen-dependent modulation of milk neutrophils competence, plasma inflammatory cytokines and milk quality during intramammary infection of Sahiwal (Bos indicus) cows. Microbial Pathogenesis, 121:131–138.(NAAS rating 2021: 8.91)
9	Sheikh, A.A., Hooda, O.K. and Dang, A.K. (2017) JAK3 and PI3K mediates bovine Interferon-tau stimulated gene expression in the blood neutrophils. Journal of Cellular Physiology (DOI: 10.1002/jcp.26296).(NAAS rating 2021: 11.55)
10	Panchal, I., Sawhney, I.K., Sharma, A.K. and Dang, A.K. (2016) Classification of healthy and mastitis Murrah buffaloes by application of neural network models using yield and milk quality parameters. Computers and Electronics in Agriculture, 06/2016; 127:242–248.(NAAS rating 2021: 9.86)